• Strengths The primary feature of GPR agonists resides

  2022-01-18

  

  Strengths The primary feature of GPR119 agonists resides in their dual mechanism of action in regulating blood glucose 1, 2, 3, 15. GPR119 agonists stimulate GLP-1 release from intestinal L D4476 as well as glucose-dependent insulin secretion and insulin promoter activity enhancement in pancreatic

• Autophagy as an important cellular process

  2022-01-18

  

  Autophagy as an important cellular process has drawn attentions to its role in cardiovascular systems [16]. Autophagy is a self-digestion and degradation process that recycles the contents of the cytosol, including macromolecules and cellular organelles, resulting in self-repair and conservation for

• Acknowledgements br Introduction The neurotransmitter

  2022-01-18

  

  Acknowledgements Introduction The neurotransmitter glycine acts through two receptors: a strychnine-sensitive glycine receptor (GlyA) and a strychnine-insensitive glycine receptor (GlyB). GlyA is localized to the neuronal membrane post-synaptic to inhibitory glycinergic neurons, whereas GlyB is

• PTMs have been shown to influence transporter kinetics both

  2022-01-18

  

  PTMs have been shown to influence transporter kinetics, both directly and indirectly (Xu & You, 2017). They do not just regulate the innate structure-function relationship driven by a transporter's global architecture, but rather are also able to regulate this relationship down to the resolution of

• Glutamate is a ubiquitous principal excitatory neurotransmit

  2022-01-18

  

  Glutamate is a ubiquitous principal excitatory neurotransmitter in the vascular disrupting agent that plays a central role in a variety of brain functions (Delgado, 2013, Hawkins, 2009). Several studies reported that CSF glutamate was associated with mental illness, including major depressive disor

• Although most of the incretin effects

  2022-01-18

  

  Although most of the incretin effects on BQ-123 australia metabolism can be secondary to their action on insulin/glucagon secretion, some evidence strongly suggests that they could also act directly on liver glucose utilization and production [4], [13], [22], [27], [34], [44]. Supporting this concep

• It has also been demonstrated that PS is

  2022-01-18

  

  It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor Ruxolitinib phosphate associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination of P

• Gal is a amino acid residue peptide comprising amino acids

  2022-01-18

  

  Gal is a 29-amino EIPA mg residue peptide, comprising 30 amino acids in humans, isolated from the porcine intestine 30 years ago (Tatemoto et al., 1983). It has been shown to be involved in the regulation of numerous processes, including neuroendocrine control of systems such as the hypothalamic–pi

• br Financial support This work was supported

  2022-01-18

  

  Financial support This work was supported by Fondation pour la Recherche Médicale (Equipe labellisée, DEQ20150331724), Inserm, University of Lille, and Agence Nationale pour la Recherche (ANR-10-LBEX-46 and ANR-10-INBS-08; ProFI project, “Infrastructures Nationales en Biologie et Santé”; “Investi

• In order to understand the

  2022-01-18

  

  In order to understand the determinants of high affinity of with amide side chain, an X-ray crystal structure of human liver FBPase in complex with was determined (). The position of phosphonate group and tricyclic scaffold of is similar to those of with no side chain, which suggests the formation o

• br Materials and methods This is a

  2022-01-18

  

  Materials and methods This is a retrospective case-controlled study. The cases were selected based on the presence or absence of preeclampsia. Women enrolled in the study delivered singleton pregnancies at our institution from June 2003 to July 2004. Preeclampsia is defined as elevated blood pres

• Arsenic is generally found in the form of iAs

  2022-01-18

  

  Arsenic is generally found in the form of iAs in arsenic plants. Arsenic is primarily metabolized in the liver through methylation processes. Human metabolism of arsenic results in the formation of the methylarsenic metabolites, MMA and DMA, which are more water soluble (Khaleghian et al., 2014; Wei

• Several named antagonist ligands have figured noticeably in

  2022-01-17

  

  Several named antagonist ligands have figured noticeably in preclinical studies, with proved clear ability to release neurotransmitters and having efficacy in preclinical animal models. Consequently, this has encouraged ongoing research on improved agents with potency, selectivity, and better drug-l

• br STAR Methods br Acknowledgments We thank the TCGA PanCanA

  2022-01-17

  

  STAR★Methods Acknowledgments We thank the TCGA PanCanAtlas Analysis Working Group. This study was supported in part by grants from the NIH (CA175486 and CA209851 to H.L., CA217842 to G.B.M., and CCSG grant CA016672); a grant from the Cancer Prevention and Research Institute of Texas (RP140462

• br Introduction Topological hedgehogs keep generating intere

  2022-01-17

  

  Introduction Topological hedgehogs keep generating interest in point-set topology as they are a rich source of counterexamples and applications (for a comprehensive survey on topological hedgehogs we refer to [1]; see also [9]). They may be described as a set of spines identified at a single poin

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