• br Discussion The etiology of autoimmune diseases including

  2021-04-23

  

  Discussion The etiology of autoimmune diseases including psoriasis is intricate and a composite of environmental and biological factors. There are very limited studies available that report the association analysis of ACE I/D polymorphism with psoriasis risk. In the current study we report on ass

• Metal ions are known not to be necessary

  2021-04-23

  

  Metal ions are known not to be necessary for catalytic activity of serine proteinases. Nevertheless, Co2+ and Ca2+ ions were found to stabilize glutamyl endopeptidase molecule [1], [7], [19]. In our previous study, we have described significant stimulating effect of Ca2+, Mg2+, and Co2+ on biosynthe

• CYP A and CYP D are among the main

  2021-04-23

  

  CYP3A4/5 and CYP2D6 are among the main drug-metabolizing enzymes in humans that are responsible for the metabolism of more than 50% of marketed drugs [19], [21]. Drugs metabolized by CYPs are prone to drug–drug interactions, thereby modifying their response [18], [32]. Metabolic inhibition is also i

• Expression of EBI and its function for

  2021-04-23

  

  Expression of EBI2 and its function for migration in vitro in T cells was recently reported (Chalmin et al., 2015, Hannedouche et al., 2011, Liu et al., 2011, Pereira et al., 2009). Pereira et al. (2009) used an EBI2 reporter mouse and found that most CD4+ T cells, but only approximately half of the

• In addition to playing important roles in the immune system

  2021-04-23

  

  In addition to playing important roles in the immune system, EBI2 is also expressed in the LDC000067 of the central nervous system (CNS), namely astrocytes, and this receptor regulates astrocyte signalling, as well as astrocyte cell migration (Rutkowska et al., 2015, Rutkowska et al., 2016a). Moreo

• br Methods br Results br Discussion Skin biopsy and microneu

  2021-04-22

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific L-Carnitine inner salt organs (Donadio et al., 2005, Donadio et al., 2012a, Don

• Thus DGK active sites remain ill defined and

  2021-04-22

  

  Thus, DGK-active sites remain ill-defined and, combined with the lack of crystal structures for mammalian DGKs, have limited our understanding of substrate and inhibitor binding. As a result, current DGK inhibitors consist of compounds with poor specificity within the DGK superfamily (de Chaffoy de

• br Introduction br Sphingolipid metabolism Sphingolipids are

  2021-04-22

  

  Introduction Sphingolipid metabolism Sphingolipids, are fundamental constituents of all eukaryotic membranes and their metabolism is carried out by a broad array of anabolic and acamprosate calcium with ceramide as their hub (for a review, (Hannun and Obeid, 2018)). Ceramide can be formed by

• br Acknowledgements br Introduction Lung cancer treatment st

  2021-04-22

  

  Acknowledgements Introduction Lung cancer treatment strategies, especially molecular targeted therapy, have progressed rapidly. However, most established treatments are for adenocarcinoma of the lung, not for squamous cell carcinoma (SQCC). SQCC constitutes approximately 30% of lung cancers, w

• Dexamethasone DEX a potent synthetic glucocorticoid drug

  2021-04-22

  

  Dexamethasone (DEX), a potent synthetic glucocorticoid drug, is effective for treatment of a range of inflammatory and autoimmune conditions as well as the reduction of side effects associated with chemotherapy. On the Czech Republic pharmaceutical market, DEX is incorporated into eighteen drugs use

• Because aspirin and ibuprofen are NSAIDs

  2021-04-22

  

  Because aspirin and ibuprofen are NSAIDs, both cause a variety of adverse effects, including stomach ulcers, stomach bleeding, coagulation disorders, Sulconazole Nitrate and cerebral microbleeds [13]. Moreover, both cause liver damage [10]. Laster [14] reported a patient with pericarditis treated w

• In the livers mefenamic acid ibuprofen

  2021-04-22

  

  In the livers, mefenamic acid, ibuprofen, and meloxicam significantly reduced expression of both 20-HETE and EETs synthesizing cyp450 genes (ANOVA, p value 0.05, Fig. 6). Control group: The lobular architecture and zonal accentuation in the liver of the control group were well preserved and kept i

• The question remained as to why hCrm was functional

  2021-04-22

  

  The question remained as to why hCrm1 was functional and mCrm1 was not in terms of Rev and HIV mRNA nuclear export, and previously we proposed three possibilities (Elinav et al., 2012). One was that human 1 25-dihydroxyvitamin d3 had a positively acting factor that somehow stabilized the hCrm1 and

• We further examined our hypothesis

  2021-04-22

  

  We further examined our hypothesis that the activation of CRF and CCK systems is responsible for the enhanced anxiety-like behavior induced by immobilization stress using two antagonists to block the expression of CRF1 and CCK2 receptors. It was found that CCK2 receptor antagonist CR2945 or CRF1 ant

• Estrogen receptors ERs belong to the third class

  2021-04-22

  

  Estrogen receptors (ERs) belong to the third class of nuclear receptors (NR3) [23]. Two different forms of ER have been described, ERα and ERβ. They are coded by two distinct genes (ESR1 and ESR2, respectively) containing 8 transcribed exons that give rise to six conserved protein domains: domains A

15025 records 590/1002 page Previous Next First page 上5页 586587588589590 下5页 Last page