• Furthermore certain components in the Melanocyte

  2019-12-04

  

  Furthermore, certain components in the Melanocyte Growth Medium seem to influence the response to UV radiation [17]: UV-induced effects on tyrosinase activity were less distinct in melanocytes cultured with phorbol 12-myristate 13-acetate [18], which was also an ingredient in our Melanocyte Growth M

• Cy5 NHS ester EphB and ephrinB mRNA levels were

  2019-12-04

  

  EphB4 and ephrinB2 mRNA levels were determined from three parts taken from each tumor, and each sample was analyzed in triplicate. The differences in the histoscores and mRNA levels of EphB4 and ephrinB2 were analyzed by Student\'s t test. The correlation coefficients were evaluated both by linear r

• br Concluding remarks br Transparency document br Acknowledg

  2019-12-03

  

  Concluding remarks Transparency document Acknowledgements Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA033572 (RS). The content is solely the responsibility of the authors and does not neces

• Introduction PGE is a major mediator

  2019-12-03

  

  Introduction PGE2 is a major mediator present at sites of inflammation [1]. It is well established that PGE2 contributes to the localized and systemic symptoms of inflammation. A key study by Portanova et al. [2] demonstrated that anti-PGE2 Vincristine were able to reverse the swelling and pain in

• At baseline mutant allele frequency of EGFR in tissue and

  2019-12-03

  

  At baseline, mutant allele frequency of EGFR in tissue and plasma samples did not correlated with anti-tumor response (Supplementary Fig. 1). Among 35 patients who were positive for cell-free DNA (cfDNA) at baseline, changes of cfDNA during treatment were analyzed. Negative conversion (NC) of cfDNA

• The modification of proteins with the

  2019-12-03

  

  The modification of proteins with the small 76-amino Ristocetin A sulfate protein ubiquitin (Ub) plays a central role in many key cellular processes. Ubiquitylation of a target protein requires the concerted action of a cascade of three enzymes (Figure 1). The ubiquitin-activating enzyme (E1) catal

• Against this backdrop we set out to identify synthetic and

  2019-12-03

  

  Against this backdrop, we set out to identify synthetic and endogenous ligands that bind directly to and regulate the activity of Nurr1. Owing to the pivotal role Nurr1 plays in producing and processing dopamine, and the need for neurons to tightly regulate dopamine levels, we postulated that the re

• br Concluding remark br Acknowledgements

  2019-12-03

  

  Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human lrrk2 daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within cancer cells also

• As the first allotetraploid fish

  2019-12-03

  

  As the first allotetraploid fish in the world, our lab selectively breed the allotetraploid hybrid fish (4nAT, 4n = 200) from the distant hybridization offspring F3 of female Red Crucian Carp (Carassius auratus red var., abbreviated as RCC, 2n = 100) and male Common Carp (Cyprinius carpio L., abbrev

• Introduction BRs are well known class of steroid phytohormon

  2019-12-03

  

  Introduction BRs are well known class of steroid phytohormones involved in the regulation of key processes of plant growth and development [1], [2], [3], [4], [5]. A lot of attention is driven to BRs in the last decade because of their undeniable functions in promoting cholecystokinin receptor re

• The molecular formula of was

  2019-12-03

  

  The molecular formula of 2 was assigned as C12H12N2O2 by the positive HRESIMS at m/z 217.0973 [M+H]+ (calcd for 217.0972), 13C NMR and DEPT spectra, having 8 degrees of unsaturation. The 1H NMR spectrum contains an ABX spin system comprised of resonances at δH 7.47 (d, J=1.9Hz, H-2′), 6.86 (d, J=8.3

• Addition of deoxyuridine to CY cultures led to a

  2019-12-03

  

  Addition of deoxyuridine to CY11 cultures led to a significant decline in the amount of uracil-DNA (Fig. 5). Deoxyuridine effectively induces the deo operon and is efficiently degraded to uracil and deoxyribose 1-phosphate by the deoA gene product, thymidine phosphorylase; a minor percentage of deox

• HMP Linker The first transcription factor TF known

  2019-12-03

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone HMP Linker of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed developmen

• Cy3 maleimide (non-sulfonated) br Transparency document br A

  2019-12-03

  

  Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0

• In contrast to chordates authentic chemokine and receptor or

  2019-12-03

  

  In contrast to chordates, authentic chemokine and receptor orthologues can be found in the agnathan fishes (Bajoghli, 2013, Kuroda et al., 2003, Nomiyama et al., 2011, Nomiyama et al., 2013); sea lamprey has at least five chemokine receptor genes, one CXCR4 (Ensembl Acc. No.: ENSPMAP00000007678) (Ku

15729 records 895/1049 page Previous Next First page 上5页 891892893894895 下5页 Last page