• The results described thus far suggest that PtAF

  2019-05-15

  

  The results described thus far suggest that PtAF-induced atrial remodeling combined with acute atrial stretch facilitates anchoring of 3-D scroll waves to the border of atrial pectinate muscle and prolongs their life span in favor of AF maintenance. However, why is it that scroll waves anchor to the

• Initial radiographs demonstrated an aggressive lesion in the

  2019-05-15

  

  Initial radiographs demonstrated an aggressive lesion in the medial condyle of the distal right femur (Figs. 1A and B). CT obtained to characterize matrix showed an aggressive lesion with a focus of dense linear matrix (Fig. 2) with intervening lucent areas. The lesion was felt to be indeterminate a

• Different ideas however emerged in

  2019-05-14

  

  Different ideas, however, emerged in the 1960s and 1970s in the minds of computational biologists interested in the theory of wave propagation in excitable media. Based on chemical [17] and numerical experiments, [18] scientists in the Soviet Union and the USA began to suggest that fibrillation was

• The concept of metronomic chemotherapy began in the s

  2019-05-14

  

  The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tum

• Recently emerging data suggest that lower frequency of IV bi

  2019-05-14

  

  Recently emerging data suggest that lower frequency of IV bisphosphonates in metastatic breast cancer has the same efficacy as monthly regimen [48]. ONJ on the other hand can be extremely symptomatic with a severely detrimental effect on quality of life. A case-control study based on risk factors f

• Adhesive interactions Adhesive interactions between myeloma

  2019-05-14

  

  Adhesive interactions: Adhesive interactions between myeloma BV6 and stromal cells play a significant role in both the homing of MM cells to the bone marrow and augmentation of the bone destructive process. These adhesive interactions result in activation of NF-κB and p38 MAP-kinase signaling, whic

• br Discussion CRT has become an

  2019-05-14

  

  Discussion CRT has become an established adjunctive treatment to optimal pharmacological therapy in patients with advanced CHF, diminished LV function, and intra-ventricular conduction delay [8]. Despite the benefits of CRT including improvements in exercise capacity, functional class, and ventri

• Por ejemplo se encuentran art culos que analizan los

  2019-05-14

  

  Por ejemplo, se encuentran artículos que analizan los sistemas curriculares, la didáctica empleada en la enseñanza, la formación de profesores, la pedagogía implementada en las clases, la educación en valores, entre otros. Se destacan varios trabajos que proyectan las reflexiones morinianas en el co

• br Should child growth replace diarrhoea as the

  2019-05-13

  

  Should child growth replace diarrhoea as the primary child health outcome for sanitation trials? We appreciate Derek Headey\'s comment in relation to our trial that the window of opportunity to plausibly affect growth faltering is from in utero up to 24 months, and therefore that sanitation trials

• With the availability of vaccines screen and treat approache

  2019-05-13

  

  With the availability of vaccines, screen-and-treat approaches, and effective drugs to treat hepatitis C virus, , and HIV infections, the question is no longer limited to what to do but now extends to how to implement. The expanding focus from basic research, drug development, and clinical trials th

• A previous study from our

  2019-05-13

  

  A previous study from our group demonstrated that the truncated form of OPG (1-194) has greater activity than the complete form, given that proteoglycans present in the bone tumor microenvironment may bind to full length OPG, thereby limiting its bioavailability and bioactivity [31]. Therefore the t

• yellow The so called driver hypothesis has

  2019-05-13

  

  The so-called driver yellow has been posited in the recent years. Optical mapping studies in isolated sheep hearts have suggested that at least some cases of AF can be maintained by high-frequency reentrant sources (rotors), usually located in the posterior LA, which result in spatially distributed

• Changing the pacemaker mode to VDD is

  2019-05-13

  

  Changing the pacemaker mode to VDD is a good approach in cases of normal sinus node function and loss of atrial lead capture, especially if atrial sensing is stable. In this case, Short AV delay is a good way to reduce the risk of R on T phenomenon which is theoretically possible if a ventricular ec

• There is strong agreement that HIV prevention should focus o

  2019-05-13

  

  There is strong agreement that HIV prevention should focus on approaches that are evidence based, but there is disagreement about how to obtain such rigorous evidence and whether this should refer only to randomised study designs. Pickles and colleagues\' report provides a concrete example of an eff

• Immediate rollout of an effective

  2019-05-13

  

  Immediate rollout of an effective and safe short-course treatment regimen is essential for the attack phase of the visceral leishmaniasis elimination programme, which aims to reduce the incidence to less than one case per 10 000 fgf receptor inhibitor at risk. A single-dose liposomal amphotericin B

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