• Alternately taurine may be affecting the rate of cell migrat

  2018-11-08

  

  Alternately, taurine may be affecting the rate of cell migration and through this mechanism accelerate cell proliferation. By increasing cell adhesion or/and accelerating migration on the plate, cells get close faster and this proximity may then generate a propitious condition for proliferation, as

• One BRCA BRCA delT and two BRCA BRCA

  2018-11-08

  

  One BRCA2 (BRCA2 6174 delT) and two BRCA1 (BRCA1 5382insC and BRCA1 185 delAG) founder mutations account for 90% of inherited BRCA1/2 mutations in patients of Ashkenazi Jewish descent (Petrucelli et al., 2010). Because 0.1% of the Ashkenazi population carries the BRCA1 5382insC mutation, we estimate

• br Introduction Breast cancer is a heterogeneous disease

  2018-11-08

  

  Introduction Breast cancer is a heterogeneous disease characterized by at least eighteen histopathological and six distinct molecular subtypes, making it extremely difficult to treat (Sørlie et al., 2001). This phenotypic diversity is considered to reflect the epithelial lineage from which a give

• Previous in vitro cell culture

  2018-11-08

  

  Previous in-vitro cell culture studies in microgravity have shown decreased osteoblast differentiation (Nabavi et al., 2011; Landis et al., 2000; Carmeliet et al., 1997), reduced osteoblast number (Hughes-Fulford and Lewis, 1996), and reduced osteoblast cell integrity (Nabavi et al., 2011). Furtherm

• There are limitations to in

  2018-11-08

  

  There are limitations to in vitro studies, the reductionist approach of focusing on a single stem cell type precludes the apexbio dilution to gestational hypoxia that has been shown to occur over longer periods of time and precludes TSC interaction with many fetal and maternal cell types (Chakrabor

• The low density lipoprotein receptor related protein LRP fam

  2018-11-08

  

  The low-density lipoprotein receptor-related protein (LRP) family is an evolutionarily conserved group of cell-surface receptors that regulate diverse biological functions in different organs, tissues, and cell types, in mammals and species of other taxa (Strickland et al., 1994; Croy et al., 2003).

• Immunocytochemistry Cells were fixed at room

  2018-11-08

  

  Immunocytochemistry. Cells were fixed at room temperature with 4% paraformaldehyde for 10min. Non-specific proteins were blocked by ultra V block (Thermo). The cells were then treated with primary selective serotonin reuptake inhibitors overnight at 4°C. Primary antibodies were against TRA-1-60 (1:

• Our results are in line with

  2018-11-08

  

  Our results are in line with previous findings showing that cellular senescence negatively correlates with reprogramming efficiency (Banito et al., 2009; Mali et al., 2008; Qin et al., 2007; Zhao and Daley, 2008; Zhao et al., 2008). The expression of p21 is controlled by p53 during the replicative s

• The gene expression changes that occurred during the differe

  2018-11-08

  

  The gene expression changes that occurred during the differentiation process were consistent with our expectations of changes that must occur during neurogenesis. For example, there was a positive enrichment for genes involved in synaptogenesis and a negative enrichment for genes involved in progres

• Recent reports have indicated the functional significance

  2018-11-08

  

  Recent reports have indicated the functional significance of FOXM1 in pluripotent cells. FOXM1 is required for the maintenance of pluripotency in mouse embryonal carcinoma (EC) cells, via direct regulation of Oct4 transcription (Xie et al., 2010). More importantly, FOXM1 is important for maintainin

• Studying the regulatory role of FGF signaling in mammalian n

  2018-11-08

  

  Studying the regulatory role of FGF signaling in mammalian neural development primarily focuses upon the VZ of the neocortex (after neural tube formation, discussed above), whereas its earlier role in neural induction is less explored. This may be due to the inaccessibility of embryonic tissues at t

• orexin agonist br Conclusion The following are the supplemen

  2018-11-08

  

  Conclusion The following are the supplementary data related to this article. Conflict of interest Acknowledgements This work was supported by FONDECYT grant # 1130760 (P.C.). Introduction Peripheral vascular disease (PVD) due to arterial insufficiency is a common problem, affecting up

• Although the disease specific phenotype identified in this

  2018-11-08

  

  Although the disease specific phenotype identified in this study will be invaluable for demonstrating the efficacy of gene based therapeutics, two major questions remain: 1) why do some patients with TRNT1 variants develop the severe syndromic disease SIFD while others (i.e. the three presented in t

• To trace host to graft connectivity of transplanted hESC der

  2018-11-08

  

  To trace host-to-graft connectivity of transplanted hESC-derived neurons, we next generated hESC lines that stably expressed the tracing and control constructs (Figures 2A and S2A). The engineered hESCs were differentiated using a protocol that results in a high yield of authentic and functional ven

• Although we followed all of the

  2018-11-08

  

  Although we followed all of the rules, we hesitate to use the phrase cGMP-compliant because this is a determination that will ultimately be made by the regulatory authorities when the entire IND package is provided to the FDA. We also note that the approval of the use of this line as part of an IND

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