br Experimental Procedures br Author Contributions br

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction We recently described an animal model in which primary genetic lesions in bone marrow (BM) stromal dihydrofolate reductase resulted in abnormal hematopoiesis in mice and the rare development of acute leukemia (Raa

A role for PI K controlling ENPs

2018-10-20

A role for PI3K controlling ENPs fits well with current ideas of how FGF, BMP, β-catenin, and FAT4 regulate ENP self-renewal and differentiation (Figure 4C). The ENPs all receive the differentiation promoting β-catenin signal from the ureteric bud, but only the synthase that receive a stromal signa

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction With the first reports on generating human induced pluripotent stem dna pk (hiPSCs) from human cells (Takahashi et al., 2007; Yu et al., 2007), the controversy regarding the ethics of research involving human embr

Recently new genome modifying methods using sequence

2018-10-20

Recently, new genome-modifying methods using sequence-specific endonucleases, such as zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (CRISPR/Cas9) systems, were developed o

Recent studies indicate that the canonical

2018-10-20

Recent studies indicate that the canonical Wnt pathway affects BMSC osteogenic differentiation. Wnt signaling can promote osteoblastic precursor differentiation into more differentiated osteoblasts and can serve as a negative regulator of adipogenesis (Glass et al., 2005; Krishnan et al., 2006). Thi

br Acknowledgments The study is supported by

2018-10-20

Acknowledgments The study is supported by funds to W-Q.G. from the Chinese Ministry of Science and Technology (2012CB966800, 2013CB945600, and 2012CB967903), the National Natural Science Foundation of China (81130038 and 81372189), the Science and Technology Commission of Shanghai Municipality (P

Fmoc-Leu-OH br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Introduction Frontotemporal dementia (FTD) refers to a group of neurodegenerative diseases caused by focal but progressive neuronal loss, astrogliosis, and spongiosis in the frontal and temporal cortices associated with abnormal intracellular acc

In this study we have developed a three step protocol

2018-10-20

In this study, we have developed a three-step protocol to differentiate hESCs to endothelial progenitor endothelin receptor antagonist (EPCs) using human recombinant laminins that are biologically relevant (LN521, LN511, and LN421) to mimic the in vivo endothelial substrata. First, vascular cell lin

Hello world!

2018-07-29