• br Conflict of interest br Introduction A

  2019-04-20

  

  Conflict of interest Introduction A large number of recent reports suggest that early repolarization (ER) and J waves are associated with the occurrence of ventricular fibrillation (VF) [1–4]. In particular, the presence of J waves in global leads, including the inferolateral leads, is thought

• br Discussion It is generally

  2019-04-20

  

  Discussion It is generally known that primary CNS melanomas are rare and difficult to diagnose prior to biopsy. According to tumor melanin content, four subtypes of malignant intracranial melanoma have been proposed, associated with different MRI image presentations. These subtypes are: 1) melano

• pleasant dream In the phase AZURE trial women were randomly

  2019-04-20

  

  In the phase 3 AZURE trial, 3360 women were randomly assigned to receive standard adjuvant systemic treatment alone (control group) or with 4mg intravenous zoledronic pleasant dream every 3–4 weeks for 6 doses, then every 3 months for 8 doses, followed by every 6 months for 5 doses, for a total of

• In addition evidence of similar resting

  2019-04-20

  

  In addition, evidence of similar resting HR׳s before exercise in the patients and in the controls implies similar autonomic activity at rest during the daytime in both groups of subjects. In contrast, previous studies have reported changes in the nocturnal HR of BrS patients [3,28]. The discrepancy

• Competing pressures for resources across sectors however mea

  2019-04-20

  

  Competing pressures for resources across sectors, however, mean that increasing the proportion of resources for health will be difficult. Efficiency gains in the health sector could help to make the case for more investment. Countries need to tackle major sources of inefficiency by doing more of the

• Having to seek various approvals with no communication betwe

  2019-04-20

  

  Having to seek various approvals, with no communication between RECs and no plan for which committee\'s decisions take priority, can lead to research bottlenecks. Many RECs, particularly those in low-income and middle-income countries (LMICs), have long turnaround times, perhaps because of infrequen

• Baseline WBC count and baseline measures of hepatic

  2019-04-20

  

  Baseline WBC count and baseline measures of hepatic and renal function for responders and nonresponders are shown in Table 1. No relationship was evident between responders to decitabine or treatment choice and baseline WBC counts, or between responders and baseline measures of hepatic function (ALT

• br Discussion A familial platelet disorder with

  2019-04-20

  

  Discussion A familial platelet disorder with a propensity to myeloid malignancy (FPD/MM) was first reported in 1978 and since then approximately 30 pedigrees with RUNX1 germline mutations have been reported in the literature [9,11]. The RUNX1 gene is composed of 10 exons (1–6, 7A, 7B, 7C and 8).

• Bacterial LPS stimulates monocytes and tissue macrophages

  2019-04-19

  

  Bacterial LPS stimulates monocytes and tissue macrophages to release TNF-α and IL-1, which then stimulate secondary response cytokines, including IL-6. In addition to hematopoietic cells, IL-6 is synthesized by many different types of nonhematopoietic cells, including endothelium, lasting for an ext

• br Discussion Early repolarization is

  2019-04-19

  

  Discussion Early repolarization is a common ECG characteristic. Its reported prevalence is 6–25% of the general population, and is particularly common in athletes [2,3,11,12]. It is now recognized that a small fraction of people with early repolarization on their ECGs develop lethal tachyarrhythm

• br Remote technologies The platforms available

  2019-04-19

  

  Remote technologies The platforms available for remote monitoring of ICDs differ. Wand-based (“inductive”) systems require patient-driven downloads relayed via telephone connections to tracking facilities [4,5]. These are becoming obsolete. This is because they demand coordination with a device c

• A year old man was hospitalized following a first syncope

  2019-04-19

  

  A 36-year-old man was hospitalized following a first syncope attack while awake at night. No history of sudden death was reported in his family. On arrival, his consciousness was clear and his vital signs were stable. An electrocardiogram (ECG) showed sinus rhythm with ST-segment elevations and J wa

• br Introduction Bone marrow adipocytes are one of the

  2019-04-19

  

  Introduction Bone marrow adipocytes are one of the most abundant cell types found in bone marrow tissue. They constitute approximately 15% of the bone marrow volume in young adults, rising to 60% by the age of 65 years old [1]. Previously considered as inert space filling cells with little biolog

• br Discussion The rate of ERP in

  2019-04-19

  

  Discussion The rate of ERP in young, healthy men in northeastern Thailand was 10.3%. This is higher than the rate reported in the US (3.3–6.1%) [12]. In the US report, the mean age of the study population was 45 years, which was older than the age of subjects in our study. Another report from the

• br Conflict of interest br Acknowledgments

  2019-04-19

  

  Conflict of interest Acknowledgments This study was supported by the National Natural Science Foundation of China (Nos. 81273501 and 81470378). Introduction Sudden cardiac death (SCD) is a tragic event and the aftermath is devastating to the surviving family and community. SCD occurs in ne

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