• The activation of Notch has been found

  2018-11-02

  

  The activation of Notch1 has been found to contribute to the invasion and metastasis of cancer via the EMT. In addition, Saad et al. (2010) showed that the overexpression of NOTCH1 induces the expression of SNAIL. In the present study, after GSI treatment the expression of NOTCH1, SNAIL1, and SNAIL2

• Delivery of Cas protein in

  2018-11-02

  

  Delivery of Cas9 protein in an RNP complex with the sgRNA avoids the need for in vivo transcription and translation. Moreover, this approach yields high expression shortly after nucleofection, followed by rapid degradation, thereby facilitating efficient gene editing while minimizing off-target rate

• A perceptron network that had

  2018-11-02

  

  A perceptron network that had previously proved to be the most sensitive to new complementary data about the model was used in the experiments. The number of endothelin receptor antagonist in the network was chosen to equal 20 (n = 20); the data used was on the correspondence between the sought-for

• The present work reports for

  2018-11-02

  

  The present work reports for the first time the synthesis of Ca5(PO4)3Cl:Eu2+ phosphor via the Pechini (citrate gel) method and the investigation of its photoluminescent properties. Experimental For synthesis of Eu2+ activated chlorapatite phosphor Ca5(PO4)3Cl stoichiometric amount of the precur

• Birinapant cost In this paper we used

  2018-11-02

  

  In this paper, we used a variation of the classical theory considering shells to be surfaces with material normals, constructed on the basis of Lagrangian mechanics [11–14]. Different applications of this theory have been described in Refs. [15–17]. The second part of the paper deals with static st

• The association between neighborhood poverty neighborhood ra

  2018-11-02

  

  The association between neighborhood poverty, neighborhood racial composition and pregnancy-related weight may be related to obesogenic neighborhoods plagued with unhealthy food environments, built environments that discourage physical activity, high crime, and widespread psychosocial stressors (Cul

• The association between neighborhood poverty neighborhood ra

  2018-11-02

  

  The association between neighborhood poverty, neighborhood racial composition and pregnancy-related weight may be related to obesogenic neighborhoods plagued with unhealthy food environments, built environments that discourage physical activity, high crime, and widespread psychosocial stressors (Cul

• Currently the precise nature of augmentation

  2018-11-01

  

  Currently, the precise nature of augmentation is not fully understood. What is known is that it is caused by a disturbance of the dopaminergic system [5]. It is believed that the increased dopaminergic state is caused by excessive stimulation of D1 compared with D2 receptors, which leads to decrease

• br Materials and methods br

  2018-11-01

  

  Materials and methods Results Microfluidic analytical devices with optical detection are considered one of the best options for developing robust and sensitive lab-on-chip devices. Key features for diagnostic and prognostic usefulness of such devices are high sensitivity and specificity, abili

• In this issue of EBioMedicine Enroth and colleagues present

  2018-11-01

  

  In this issue of EBioMedicine, Enroth and colleagues () present a comprehensive study that analyzes the individual contribution of factors related to the collection and long-term sample storage in a highly homogenous group of Northern European subjects (). Taking advantage of the sampling strategy o

• In a previous study we firstly

  2018-11-01

  

  In a previous study, we firstly uncovered the crucial role of NFAT5 in the development of autoimmune disease by demonstrating that NFAT5-deficient mice showed a marked Bafetinib of antibody-induced arthritis (Yoon et al., 2011). Moreover, we have demonstrated that NFAT5 is highly expressed in the s

• br RNA interference RNAi and ectopic expression To address t

  2018-11-01

  

  RNA interference (RNAi) and ectopic expression To address the functionalities of the identified proteins, we silenced the coding genes of these proteins in a normal colonic fibroblast cell line, CCD-18Co, and then performed coculture assays with colon cancer cells. Follistatin-related protein 1 (

• Collapsed across groups vACC activation did

  2018-11-01

  

  Collapsed across groups, vACC activation did not show a significant correlation with age (r(48)=0.23, p=0.1). However, when assessing these correlations in each group separately, activation in the vACC ROI sphere correlated significantly with age in TD youth (r(17)=0.464, p=0.045), but not UAS or AS

• The present study examined the effects of increasing load

  2018-11-01

  

  The present study examined the effects of increasing load, with six difficulty levels in a verbal WM task, and how load-dependent change in pten pathway function differed in children and adults. Prior developmental visual verbal WM studies that included load as a manipulation used complex tasks that

• The model is rich enough

  2018-11-01

  

  The model is rich enough to be applied to the development of behavior, individual differences in behavior, changes in structural properties of processing systems, and data on heritability, but of course, it is highly simplified. The current model had the following limitations. First, the objective w

15689 records 1034/1046 page Previous Next First page 上5页 10311032103310341035 下5页 Last page