• In vivo study showed that the CYP A activity

  2021-08-12

  

  In vivo study showed that the CYP3A activity was increased, when morroniside (10, 30 and 90 mg/kg, i.g.) was daily for seven consecutive days. Further, RT-PCR analysis showed that the induction of mRNA Purmorphamine synthesis by morroniside (10, 30 and 90 mg/kg, i.g.) was 1.13-, 1.43- and 1.79-fold

• Previous studies have shown the harmful

  2021-08-11

  

  Previous studies have shown the harmful effects of NEFA on ovarian functionality, such as inhibition of bovine granulosa cell survival and proliferation, steroidogenesis, and follicular development and alteration in oocyte development [36,45,46]. Therefore, the higher levels of NEFA found in the fol

• br Introduction The cys loop ligand gated

  2021-08-11

  

  Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2]. Each subunit that makes up the pentameric LGIC architecture possesses a dicysteine bri

• br Introduction Cell transplantation therapies using embryon

  2021-08-11

  

  Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or a cool way to improve have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of groups h

• water br Discussion EFTs are sarcomas with almost undifferen

  2021-08-11

  

  Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular water on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 immunohistochem

• br Conclusions Nanoparticles can be used to modulate the cat

  2021-08-11

  

  Conclusions Nanoparticles can be used to modulate the catalytic activity of various industrially and clinically useful enzymes, as well as pH, temperature and storage stabilities, which will enable the process to occur more efficiently and less costly. The interaction between an enzyme and nanopa

• Importantly MPO is not only a marker of cardiovascula

  2021-08-11

  

  Importantly, MPO is not only a marker of cardiovascular disease but also emerges as a critical mediator of vascular inflammatory disease: Liberated MPO binds to the endothelium in a leukocyte-independent manner, is subsequently taken up by the endothelium and transcytoses and accumulates in the sube

• We propose that unlike other autophagy genes

  2021-08-11

  

  We propose that, unlike other autophagy genes, the specific increase in the expression of IRGM by pEIF2A plays a major role as a checkpoint allowing host cell survival by autophagy or host cell elimination by necroptosis. The localization of IRGM to the mitochondrial inner membrane, its ability to i

• Programmed cellular death or apoptosis is a process

  2021-08-11

  

  Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011). Nevertheless, apoptosis s

• br Introduction As a strong analgesic morphine

  2021-08-11

  

  Introduction As a strong analgesic, morphine is often used to treat acute and chronic pain. However, morphine is a substance with low lipid solubility that slowly enters the nerve tissue through the blood–brain barrier and produces neurotoxicity. Morphine-induced neurotoxicity can be produced aft

• A topological property P is said to be cut point

  2021-08-10

  

  A topological property P is said to be cut point hereditary [3] if whenever a space X has property P, then, for every there exists some separation of such that each of and has property P. A space X is called connected ordered topological space (COTS) [5] if it is connected and has the property: if

• br Overall system architecture In this section we provide

  2021-08-10

  

  Overall system architecture In this pde-5 inhibitors section we provide a description of the system under study, and its surrounding environment, on an “as is” basis. The architecture presented in the following is the one currently adopted on-field by ASTS (e.g., at Rome train station). The Tra

• br Conclusions and future perspectives It is

  2021-08-10

  

  Conclusions and future perspectives It is now evident that selective ETA or nonselective endothelin receptor antagonism provides therapeutic potentials against a variety of cardiovascular diseases such as hypertension, PAH, and diabetic microvascular dysfunction (Fig. 1). However, PAH is currentl

• In humans the ER is encoded by the gene

  2021-08-10

  

  In humans, the ERα is encoded by the gene ESR1, located on chromosome 6, locus 6q25.1 (Gosden, Middleton, & Rout, 1986). In addition to the full-length ERα isoform (66kDa), several shorter isoforms (36kDa, 46kDa) have been identified as a result of the presence of alternate start codons, or as produ

• wst-1 receptor To further investigate mechanisms of rXCI we

  2021-08-10

  

  To further investigate mechanisms of rXCI, we generated female ESCs with a homozygous RlimKO. We found that these wst-1 receptor undergo XCI in vivo but that XCI in vitro is strongly influenced by culture conditions, including both method of differentiation and O2 levels. Our results demonstrate Rl

15689 records 574/1046 page Previous Next First page 上5页 571572573574575 下5页 Last page