• MAPKs are a family of phosphorylating enzymes that orchestra

  2021-01-26

  

  MAPKs are a family of phosphorylating enzymes that orchestrate various cellular response in proliferation, apoptosis, inflammation, stress response, and energy metabolism [11]. There are at least four major members including extracellular signal-regulated kinase 1 and 2 (ERK1/2), p38 mitogen-activat

• It is well established that a number of

  2021-01-26

  

  It is well established that a number of intracellular signaling pathways mediate sensitization of sensory neurons (Gold and Gebhart, 2010, Richardson and Vasko, 2002). This redundancy could be advantageous since it provides diversity in initiating and maintaining hypersensitivity in response to inju

• br Experimental br Results and discussion br Conclusion

  2021-01-26

  

  Experimental Results and discussion Conclusion Acknowledgements This work was funded by the National Natural Science Foundation of China (81572080, 81873972and81873980), the National Science and Technology Major Project of the Ministry of Science and Technology of China (2018ZX10732202),

• There are conflicting studies on ET

  2021-01-26

  

  There are conflicting studies on ET axis and its relationship with clinicopathologic parameters in various cancers. Endothelin axis expression in the tissue and in blood has been associated with advanced cancer characteristics in colorectal, breast, and prostate cancer, while showing no linkage to c

• At present there have been relatively few studies that evalu

  2021-01-26

  

  At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal Sodium Danshensu nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37]. Further research on these relationships is nee

• The other scenario pertaining to the significance of H

  2021-01-26

  

  The other scenario pertaining to the significance of H2AX phosphorylation is based on the fact that the initiation of DNA fragmentation by CAD facilitates the chromatin condensation that occurs concurrently [15]. Apoptotic DNA fragmentation and chromatin condensation are important for the efficient

• Propylthiouracil receptor br Introduction Acinetobacter baum

  2021-01-26

  

  Introduction Acinetobacter baumannii is a gram-negative opportunistic pathogen that causes nosocomial infections including pneumonia and bloodstream infections which is associated with an increased mortality and multi-drug resistance [[1], [2], [3]]. A. baumannii was rated as one of the critical

• Palliative surgeries for refractory epilepsy

  2021-01-26

  

  Palliative surgeries for refractory epilepsy include vagus nerve stimulation and corpus callosotomy. Among 220 individuals with CDD with parent-entered data, 17% had a vagus nerve stimulation implanted and 69% of parents reported reduced seizure frequency. These data are consistent with a case repor

• Alternatively procedural factors may have contributed

  2021-01-26

  

  Alternatively, procedural factors may have contributed to the conflicting results. For instance, in order to have a more circumscribed area of drug diffusion, a volume of 0.05μl was injected in experiment 1b, which is four times lower than the one used in the mentioned plus-maze investigation. Besid

• The P H activity and

  2021-01-26

  

  The P4H activity and the large number of 4-Hyp residues that are formed, amounting to half of all the Pro residues or 10% of all residues, have been identified as having a clear role in the structure and chemistry of the triple helix [3]. The role of the rare 3-Hyp residues is less clear and is stil

• Next we elucidated that the Mtb

  2021-01-26

  

  Next, we elucidated that the Mtb enolase binds to host plasminogen with a high affinity. The KD value of 360nM for this interaction suggested an avid binding between the two proteins in vivo. This observation is also in conciliation with the observed KD values for enolase-plasminogen interactions in

• br Introduction Cancer related inflammation is associated wi

  2021-01-26

  

  Introduction Cancer related inflammation is associated with poor prognosis and reduced survival in numerous human malignancies. Expansion of myeloid derived immune Deacetylase Inhibitor Cocktail in response to tumor-secreted factors largely contributes to the heightened systemic and intra-tumoral

• br Orthotopic liver transplantation OLT is the only

  2021-01-26

  

  Orthotopic liver transplantation (OLT) is the only curative therapy available for patients with end-stage liver disease. The surgical procedure of liver transplantation inherently involves cold ischemia during graft preservation , followed by reperfusion of the transplanted graft which results in

• Exposure to ultraviolet radiation with sunlight is generally

  2021-01-26

  

  Exposure to ultraviolet radiation with sunlight is generally accepted as the major cause of basal-cell carcinoma (Gallagher et al., 1995). The risk of this disease is significantly increased by age. Skin cancers are the most common tumours of the head and neck region and their prevalence shows progr

• The idea that ASB can drive compartment

  2021-01-26

  

  The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma SF1670 receptor [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2) cells [

15689 records 686/1046 page Previous Next First page 上5页 686687688689690 下5页 Last page